Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles
 

Open Access

Original Research



Hemodynamic response to administration of vasopressors among patients with septic shock

Sneha Jyothi A N, Sushma Muraraiah, Vijaya Kumar.

Abstract
Background: Septic shock is characterized by refractory hypotension with a mortality of >50%. Early fluid resuscitation, if failed, vasopressors are recommended to maintain mean arterial pressure (MAP) of 65 mmHg to restore organ perfusion. Noradrenaline (NA) is the vasopressor of choice but can be associated with adrenergic hyposensitivity and adverse effects on prolonged high-dose treatment. Hence, the addition of arginine vasopressin (AVP) to reduce the dose of NA is recommended. In view of the paucity of data in our setup, the present observational study was undertaken.

Aims and Objectives: The present study was conducted to analyze the hemodynamic response to vasopressors among patients in septic shock and to compare the same among patients receiving NA alone or NA + AVP.

Materials and Methods: All consenting adult patients >18 years with septic shock receiving vasopressors were included in the study. Hemodynamic variables such as systolic and diastolic blood pressure and MAP were noted at baseline, 30 min, 1, 6, 24, and 48 h and the same was compared between patients receiving either NA alone or NA + AVP.

Results: The median age was 45 years with male preponderance. At admission, median MAP was 63 mmHg. On administration of vasopressors, target MAP was achieved by 1-h and maintained in both the groups of patients receiving NA or NA + AVP. No significant differences were noted in terms of hemodynamic parameters among patients receiving NA alone or NA + AVP.

Conclusion: As per the surviving sepsis guidelines 2018, vasopressor administration was initiated and the target MAP of >65 mmHg was achieved by 1 h, sustained over 48 h. No significant differences were noted among the patients receiving NA alone or NA + AVP in terms of hemodynamic variables.

Key words: Septic Shock; Mean Arterial Pressure; Noradrenaline; Arginine Vasopressin



Similar Articles

Application of atmospheric pressure glow discharge generated in contact with liquids for determination of chloride and bromide in water and juice samples by optical emission spectrometry.
Gorska M, Pohl P
Talanta. 2022; 237(): 122921

Network analysis of psychological factors related to academic pressure faced by medical students in the central and highland regions of Vietnam.
Nguyen MT, Nguyen TG, Tran TTA, Nguyen TTN, Le DD, Nguyen TTB, Hoang HH, Ho TLD, Tran BT
Medical education online. 2022; 27(1): 2007577

Under pressure: Women's leadership during the COVID-19 crisis.
Bruce R, Cavgias A, Meloni L, Remígio M
Journal of development economics. 2022; 154(): 102761

MR Imaging of Vascular Malformations and Tumors of Head and Neck.
Abdel Razek AAK, Elmokadem AH, Soliman M, Mukherji SK
Magnetic resonance imaging clinics of North America. 2022; 30(1): 199-213

Effect of temperature and humidity on coronavirus infection in Pakistan.
Akbar F, Suleman M, Israr M, Ali SS, Zaman N, Khan O, Ali J, Ahmad W, Rahat MA, Rasool A, Shah M, Hussain Z, Ali M
Gene reports. 2022; 26(): 101441


Full-text options


Latest Statistics about COVID-19
• pubstat.org


Add your Article(s) to Indexes
• citeindex.org






Covid-19 Trends and Statistics
ScopeMed.com
CiteIndex.org
CancerLine
FoodsLine
PhytoMedline
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.



ScopeMed Web Sites