Novel drug delivery system offer several advantages which could outweigh the benefits of other drug delivery systems. The transdermal drug delivery system being one of them offers supremacy by by-passing the first pass metabolism which eventually helps in eradication of gastrointestinal irritation. However, the major drawback of the transdermal drug delivery system is the hindrance created via stratum corneum. This protective barrier of the skin does not allow required penetration of the drug via skin into the systemic circulation. Thus, in order to overcome this hurdle, a replacement to this type of novel drug delivery system namely microneedle drug delivery system helped improve various pitfalls of transdermal drug delivery system like skin barrier function, restrictions towards using of specific drugs only, bioavailability, patient compliance, diffusion rate, plasma concentration level, etc. A microneedle drug delivery system thus is advancement to transdermal drug delivery system which includes delivery of drug via microneedle into systemic circulation thus increasing patient compliance and avoiding problems rendered by TDDS.
Key words: Transdermal delivery; Microneedle; Microneedle patents; Microneedle applications, Skin barrier function
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