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Analysis of PIK3CA expression to clinicopathology features of colorectal cancer in Makassar, Indonesia

Ibrahim Labeda, Erwin Syarifuddin, Julianus Aboyaman Uwuratuw, Ilham Jaya Pattelongi, Muhammad Faruk.

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Introduction: Phosphatidylinositol 3-Kinase (PI3KCA) were signal pathways that play important roles in cell proliferation, resistance to apoptosis, angiogenesis, and metastasis in CRC. The effect of PI3K in the growth and development of tumor was mediated by Akt (Kinase serine-threonine) and was correlated with cell proliferation, apoptosis inhibition, and clinicopathological parameter difference. There is currently no data on PI3KCA to Colorectal Cancer clinicopathology in Makassar.
Methods: This is an observational study with a cross-sectional design. As many as 55 samples fulfilled inclusion criteria and were subjected to immunohistochemistry examination using PIK3CA Monoclonal Antibody with semiquantitative analysis. Data were analyzed with the Chi-Square test and FisherÂ’s exact test.
Results: Analyzed between PI3KCA expression and Clinicopathology features was not one negative PI3KCA expression was found in the right colon. Meanwhile, 30.8% positive PI3KCA expression was found in right colon (p = 0.009). Similar results were found in the histopathological type. Not one negative PI3KCA expression was found in mucinous histopathological type, while 28.2% positive PI3KCA expression was found (p = 0.014).
Conclusion: Frequency of PI3KCA mutation was 70.9% out of total samples of CRC patients in Makassar. PI3KCA expression was found to be significantly related to tumor location and histopathological type but insignificantly related to the clinical stage.

Key words: PI3KCA, PI3K, Phosphatidylinositol, Clinicopathology, Colorectal Cancer

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