Probiotics could have beneficial effects beyond gastrointestinal health, as they were found to improve certain metabolic disorders such as hyperglycemia and hyperlipidemia. This study aimed to investigate the effect of probiotic Lactobacillus plantanrum on progression of streptozotocin (STZ)-induced type2 diabetes in male rats.
The animals were divided into: Normal control (NC); Probiotic control (PC) rats administered Lactobacillus plantarum 107 CFU/ml/orally/daily for 28 days; STZ-Diabetic control rats (DC, 50 mg/kg/i.p.); Treated diabetic (TD) rats that received Lactobacillus plantarum. Fasting blood glucose, glycosylated hemoglobin, plasma insulin, blood lipid profile, and cardiac markers (creatine kinase; CK and lactate dehydrogenase; LDH) were recorded.
L. plantarum administration to diabetic rats prevent body weight decreasing and caused a significant (P=0.0001) decrease of serum glucose after the first week by (22.34%) from the initial value as compared to diabetic rats. Furthermore, at the end of experiment, we observed a significant (P
Key words: Keywords: Probiotic; Type 2 diabetic rats; Lactobacillus plantarum; Hyperglycemia; Hyperlipidemia; Cardiac markers.
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