Gout is the most common inflammatory arthritis worldwide. Untreated gout causes severe pain and affects quality of life. Zingiber zerumbet is a well-known traditional plant with anti-inflammatory and antioxidant properties. This study was conducted to evaluate the effects of Z. zerumbet extract in gout-induced rats. In this study, 30 male Sprague-Dawley rats were divided into five groups (6 rats in each group): i) normal control group received normal saline and tween 80; ii) model group injected with monosodium urate (MSU) crystals solution; iii) positive control group received 10 mg/kg celecoxib drug; iv) Z. zerumbet extract at 200 mg/kg and v) Z. zerumbet extract at 400 mg/kg. The extract was orally administered for 14 days. Rats of all groups (except the normal control group) were injected with MSU crystals (50 μl) into the ankle joint on day 11. The ankle joint was measured before injection, 10, 24, 48 and 72 hr after injection. On day 14, all rats were sacrificed. Blood and tissue samples were obtained for inflammatory and oxidative stress biomarkers analysis. In this study, the ankle joint diameter rate was significantly reduced by Z. zerumbet at 200 mg/kg and 400 mg/kg (p
Key words: arthritis, gout, inflammation, monosodium urate, Zingiber zerumbet
|
