Infections in poultry cause economic loses and in some cases human health problem worldwide. The most common infections are associated with salmonellosis, colibacillosis, campylobacteriosis, and others. Infections caused by these pathogens, often through poultry products, are also serious public health issues. The practice of phage therapy, which uses bacterial viruses (phages) to treat bacterial infections, has been around for almost a century. The universal decline in the effectiveness of antibiotics has generated renewed interest in revisiting this practice. The high success rate and safety of phage therapy in comparison with antibiotics are partly due to their specificity for selected bacteria and the ability to infect only one species, serotype or strain. Conventionally, phage therapy relies on the use of naturally-occurring phages to infect and lyse bacteria at the site of infection. This mechanism does not cause the destruction of commensal bacterial flora. In this review, we highlighted recent diverse advances in the field of phage research, going beyond bacterial control using whole phage, diagnostics, novel drug delivery systems, phage-based vaccine, bio-nanotechnology and application of bacteriophages in poultry production as an alternative means of eliminating pathogens.
Bacteriophage, Bacteriophage-based tools, Bacteriophage therapy, poultry
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