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Original Article

ECB. 2015; 4(3): 121-127


SYNTHESIS AND CHARACTERIZATION OF NEW - LACTAMS USED TO DECREASE BLOOD CHOLESTEROL LEVEL

Z. Yahya Kadhim, M. Shakir Magtoof.




Abstract

This study is concerned with the synthesis and characterization derivatives of the mono/bis, syn and anti-γ-lactams 2a-2i. These compounds
were synthesized by reacting phenylsuccinic anhydride with the appropriate Schiff base (imines) 1a-1i in moderate yields (50-92 %). The
structures of these γ-lactams were established on the basis of the spectral data like IR, 1H-NMR,13C-NMR, HSQC 1H13C-NMR, MS.

Key words: γ- Lactams, cycloaddition, phenylsuccinic anhydride, 13C NMR, HSQC 1H13C-NMR.






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