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Changes in thiol/disulfide homeostasis in patients with chronic kidney disease

Ibrahim Solak, Ibrahim Guney, Seher Mercan, Ozcan Erel, Salim Neselioglu, Cigdem Damla Cetinkaya, Mehmet Ali Eryilmaz.

Abstract
Thiol/disulfide homeostasis (TDH) is a new marker of oxidative stress. In this study, we would like to determine the changes in TDH in hemodialysis (HD) patients with chronic kidney disease (CKD). This cross-sectional study was conducted in the Nephrology Clinic of Konya Training and Research Hospital. A total of 197 individuals including 75 HD patients, 41 end stage renal disease (ESRD) patients (having stage 3-5 CKD but not receiving hemodialysis), and 81 healthy controls were enrolled in the study. Serum native thiol, total thiol, and disulfide levels were measured with a new method developed by Erel and Neselioglu. It was determined that there was a statistically significant difference in the mean age, body mass index (BMI), modification of diet in renal disease (MDRD), and creatinine level between the three groups (p

Key words: Hemodialysis, chronic kidney disease, oxidative stress, thiol/disulfide homeostasis



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