A new series of 3-(4-fluorophenyl)benzo[g]indazoles derivatives have been synthesized by simple, high yielding routes. The key step in the
construction of the 3-(4-fluorophenyl)benzo[g]indazoles nucleus involves the reaction of α-tetralone with 4-fluorobenzaldehyde followed
by reaction with hydrazine or thiosemicarbazide. The newly synthesized compounds were evaluated for their antimicrobial activity and
compounds 5, 6b, 12d and 16b demonstrated inhibitory effects on the growth of a wide range of microbes.
Key words: benzo[g]indazoles, pyrazole, thiazole, antimicrobial activity, minimal inhibitory concentration