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Effect of myrtus communis extract on serum cytokines in angiotensin dependent hypertensive rats

Zatiye Ayca Cevikelli Yakut, Busra Ertas, Ali Sen, Goksel Sener.




Abstract

In angiotensin dependent hypertension, high blood pressure and elevated angiotensin 2 levels lead to inflammation by increasing the pro-inflammatory cytokine levels. Since Myrtus communis have showed anti-inflammatory acvtivity in ethnobotanical researches and experimental studies, we investigated the effect of Myrtus communis extract against inflammation in a rat model of angiotensin dependent hypertension. Wistar albino rats were divided as sham-operated control, RVH and Myrtus communis extract-treated RVH groups. Left renal arteries of the rats were implanted with silver clip. Indirect blood pressure measurement of rats was provided with tail-cuff method before the surgery, 3 and 9 weeks after the surgery. Myrtus communis extract (100 mg/kg, orally) or vehicle was administered for 6 weeks. At the end of the study, serum samples were collected to investigate tumor necrosis alpha (TNF-α), interleukin-1 beta (IL-1β) and IL-6 levels. RVH resulted in significant increases in these proinflammatory cytokine levels. In the Myrtus communis extract treatment group, this increasement was abolished. The present data demonstrated that Myrtus communis attenuates RVH-induced inflammation.

Key words: Renovascular hypertension, angiotensin 2, inflammation, cytokines, Myrtus communis






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