Placental site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasia with unclear risk factors. The nonspecific and uncharacteristic clinical and biochemical presentation and the rarity of these malignancies makes the diagnosis of PSTT often difficult thereby leading to a low preoperative diagnosis. Here, we report a case of PSTT with nonspecific and uncharacteristic behavior leading to dilemma in diagnosis and who also had vascular tumor emboli on histopathological examination. She was treated with hysterectomy for PSTT, and subsequently developed an occult isolated CNS metastasis for which she received 6 cycles of EMA/EP chemotherapy. At the latest follow-up, the patient's course was satisfactory, and she exhibited no signs of tumor recurrence. The rarity, uncharacteristic behavior and its successful outcome in management mandates this case to be reported.
Placental site trophoblastic tumor (PSTT), Gestational trophoblastic disease (GTD), chemotherapy, Immunochemistry
Disparities in Genetic Testing for Heritable Solid-Tumor Malignancies.
Dillon J, Ademuyiwa FO, Barrett M, Moss HA, Wignall E, Menendez C, Hughes KS, Plichta JK
Surgical oncology clinics of North America. 2022; 31(1): 109-126
Exploring the Alzheimer's disease neuroepigenome: recent advances and future trends.
Zhang H, Elefant F
Neural regeneration research. 2022; 17(2): 325-327
MTA1, a metastasisâ€‘associated protein, in endothelial cells is an essential molecule for angiogenesis.
Ishikawa M, Osaki M, Uno N, Ohira T, Kugoh H, Okada F
Molecular medicine reports. 2022; 25(1):
Editorial: Novel therapeutic approaches in chronic kidney disease and kidney transplantation: the draw of evolving integrated multimodal approaches in the targeted therapy era.
Tantisattamo E, Hanna RM, Kalantar-Zadeh K
Current opinion in nephrology and hypertension. 2022; 31(1): 1-5
Growth differentiation factor 5: a neurotrophic factor with neuroprotective potential in Parkinson's disease.
Goulding SR, Anantha J, Collins LM, Sullivan AM, O'Keeffe GW
Neural regeneration research. 2022; 17(1): 38-44