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JNBS. 2019; 6(3): 219-222

Role of 5-hydroxytryptamine receptor 2A gene in eating disorders

Nuri Sertac Sirma, Can Akpınaroğlu, Korkut Ulucan, Canan Sercan.


Aneroxia Nervosa (AN) and Blumia Nervosa (BN) are eating disorders with complex structures. These disorders, which have strong evidence of genetic linkage, are often accompanied by anxiety disorder, mood disorder, obsessive compulsive disorder and perfectionism. Recent studies are investigating the biological origins of these disorders rather than the familial inheritance. Eating disorders and anxiety disorders have several characteristics in common. In family and twin studies indicates that 5-Hydroxytryptamine (5-HT2A) Receptor 2A have an important role in AN and BN pathogenesis. Future studies in this field will indicate the importance of the serotonergic system and its biological markers in the treatment of these nutritional disorders. Predisposition and farmacogenetic studies with larger sample groups will produce the importance of gen in nutritional disorders with more reliable arguments and will provide important information to physicians in terms of treatment approach.

Key words: gene, 5-hydroxytryptamine, receptor, 2A, eating disorders

Article Language: Turkish English

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