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Original Research

JPAS. 2019; 19(1): 121-125


SYNERGISTIC SUSCEPTIBILITY OF THE ACTIVITIES OF METANOL, HEXANE, ETHYL ACETATE AND WATER EXTRACTS OF ALOE VERA AND HYPTIS SUAVEOLENS AGAINST INFECTIONS OF A PROTOZOAN; GIARDIA LAMBLIA AMONG CHILDREN WITH DIRRHOEA

Abdulrahman Omammegbe, Samaila B. Adamu, Panda Sam Mao, Abdullahi Aliyu, Sahal M. R..


Abstract

Background. Giardia lamblia (G. lamblia), enteric pathogen, prevalent among children worldwide causing both asymptomatic carriage and diarrhoeal illness, the prevalence ranges between 1% and 30% depending on community and age groups surveyed, the reservoirs are humans, modes of transmission is through the consumptions of water, foods, vegetables that are contaminated with cysts or oocysts, from person to person which occurs by hands to mouths transfer of cysts of feces from infected individuals.
Method. The study was conducted between June, 2018 and February, 2019. Antimicrobial activities of the crude extracts obtained from Aloe vera and Hyptis suaveolens were investigated individually and combined in an attempt of evaluating their medicinal potentials as anti-giardiasis in relations to diarrhoea in diarrhoeagenic children in Bauchi State, Nigeria. Phytochemical screening revealed the presence of saponins, tannins, alkaloids, flavonoids, terpenoids, alkaloids, phenols. An in-vitro susceptibility assay method was performed. The parasites mortality was obtained by counting in hemocytometer under a light microscope, trophozoite viability was evaluated microscopically in eosin-stained (0.01%) preparations and in addition, their morphological criteria were observed. The parasites mortality determined were expressed as mean ±SEM, differences between means were statistically analysed and compared.

Key words: Aloe vera, Hyptis suaveolens, Giardia lamblia, Children, Extraction solvents and Diarrhoea.






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