Vanillic acid (4-hydroxy-3-methoxybenzoic acid) is a phenolic acid found in many plant extracts. It is used as a flavoring and scent agent and produces a pleasant, creamy odor. It is widely used in many applications for therapeutic purposes to flavoring agent. Molecularly imprinted polymers (MIP) of vanillic acid were synthesized by precipitation polymerization with a non covalent approach for the extraction from blood serum. Three different imprinted polymers have been synthesized with varying molar ratio of monomer. The synthesized polymer particles were characterized by using Fourier Transform Infrared spectroscopy (FT IR) and Scanning Electron Microscopy (SEM). The extraction efficiency of highly selected imprinted polymer of vanillic acid from spiked blood serum was about 80%.
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