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Mecanism and inotropic actions of the water exracts of the leaves and seeds of Datura metel (solanaceae) on isolated frog's heart

David Emery Tsala,Hacheked Mbida,Nga Nnanga,Esther Tom Ngo Lemba,Solomon Habtemariam,Jacqueline Minkande Ze.


Datura metel leaves are used by athletes to enhance their performances. The water extract of the leaves and seeds was tested for their cardiotonic effect. LangherdoffÂ’s model for the measurement of the mechanical activity of isolated amphibian heart in ventricular perfusion was used to evaluate some parameters of cardiac contractility. The effect of the extracts was also compared to sympathetic agonist and antagonist. The leaves and seed extracts induced significant (p

Key words: Datura metel, inotropism, anticholinergic, isolated heart

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