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Review Article



Possible antithrombotic properties of propolis

Naoki Ohkura,Keiji Maruyama,Fumiko Kihara Negishi.

Abstract
The formation of thrombi in blood vessels results in thrombosis that is responsible for considerable morbidity and mortality because it is associated with arterial diseases such as myocardial infarction, stroke and peripheral occlusive disease in addition to venous thromboembolic disorders. Pharmaceutical agents such as anticoagulant agents and antiplatelet agents are applied at the prevention of the recurrence of thrombotic disorders. However, the use of these pharmaceuticals can result in side effects such as bleeding, as well as renal and hepatic disorders. The prevention and treatment of diseases using functional foods and alternative medicines has recently attracted attention. Functional foods and alternative medicines with possible antithrombotic properties that have been used for many years are now receiving significant focus in terms of the treatment and prevention of thrombosis. Because they have already been used for so long, they are likely to be safe. Propolis is a hive product comprising resinous materials collected by bees from plants and it includes various chemical compounds. Various biological activities of propolis have been indicated and propolis is used as folk medicine and health supplement worldwide. This report reviews the possibility of using propolis as an antithrombotic agent.

Key words: honeybee, Brazilian propolis, thrombosis, platelet aggregation, plasminogen activator inhibitor 1, caffeic acid phenethyl ester



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