In the present work, we describe a low-cost, unreported and simple procedure for biosynthesis of zinc oxide nanoparticles (ZnO NPs) using
Bacillus subtilis as eco-friendly reducing and capping agent. The synthesized ZnO NPs were characterized by UV-Vis spectroscopy, FTIR,
XRD, SEM, TEM, PL and TGA techniques. The biosynthesis methods were carried out for its intrinsic advantages, as it is simple, costeffective, environment-friendly and can be easily scaled up for large scale synthesis. The prepared nano-particles were used as catalyst for
the fast and efficient synthesis of steroidal thiophenes. The one pot three-component mixture of steroidal ketones (1-3), malononitrile/ethyl
cyanoacetate and elemental sulfur were converted into the corresponding steroidal thiophenes (4-9) in moderate to high yields with
excellent selectivity.
Key words: ZnO nanoparticles; Bacillus subtilis; steroidal thiophenes.
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