Abstract

The starting material, 5-amino-3,4-diphenylthieno[2,3-c]pyridazine-6-carbonitrile was subjected to subsequent reactions with aromatic and
heteroaromatic aldehydes, benzylchloride, cyclohexanone, phenyl isothiocyanate, hydroxylamine hydrochloride and hydrazine hydrate to
afford new polycyclic compounds. The new synthesized compounds were confirmed by their infrared, mass spectrum, 1H-NMR, and
elemental analyses, and further screened for antimicrobial activity.

Key words: Thienopyridazines; pyrrolothienopyridazines; pyrimidothienopyridazines, pyrazolothienopyridazines; pyridazinothienoquinolines; synthesis; antimicrobial activity.