Home|Journals|Articles by Year

Directory for Medical Articles
 

Original Article



Assessment of vascular reactivity at different time-course on streptozotocin-induced diabetic rats

Zurina Hassan, Aidiahmad Dewa, Mohd Z. Asmawi, Munavvar Z. Abdul Sattar.


Abstract
Cited by (3)

Objective: Impairment of vascular reactivity in diabetes may be due to endothelium and/or vascular smooth muscle dysfunction. This study aimed to verify the role of endothelium and vascular smooth muscle in diabetes at different time-course after streptozotocin (STZ) administration.
Method: Endothelium-intact and denuded aortic rings obtained from non-diabetic and diabetic rats at different time-course (1-4 weeks) were subjected to graded concentrations of potassium chloride (KCl) and phenylephrine (PE), L-NAME and indomethacin, respectively.
Results: Vasoconstrictor responses (maximum contractility, Emax) to KCl in endothelium-intact and denuded aortic rings were significantly influenced at week 4 (P

Key words: Aortic rings; Indomethacin; L-NAME; Phenylephrine; STZ-induced diabetes; Vascular reactivity






Full-text options


Share this Article



Online Article Submission
• ejmanager.com







eJManager.com
Review(er)s Central
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.