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Assessment of vascular reactivity at different time-course on streptozotocin-induced diabetic rats

Zurina Hassan, Aidiahmad Dewa, Mohd Z. Asmawi, Munavvar Z. Abdul Sattar.

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Objective: Impairment of vascular reactivity in diabetes may be due to endothelium and/or vascular smooth muscle dysfunction. This study aimed to verify the role of endothelium and vascular smooth muscle in diabetes at different time-course after streptozotocin (STZ) administration.
Method: Endothelium-intact and denuded aortic rings obtained from non-diabetic and diabetic rats at different time-course (1-4 weeks) were subjected to graded concentrations of potassium chloride (KCl) and phenylephrine (PE), L-NAME and indomethacin, respectively.
Results: Vasoconstrictor responses (maximum contractility, Emax) to KCl in endothelium-intact and denuded aortic rings were significantly influenced at week 4 (P

Key words: Aortic rings; Indomethacin; L-NAME; Phenylephrine; STZ-induced diabetes; Vascular reactivity

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