In the literature, many cases of abnormal uterine bleeding associated with selective serotonin reuptake inhibitors as an antidepressant treatment side effect have been reported. However, abnormal uterine bleeding associated with bupropion, a norepinephrine-dopamine reuptake inhibitor, has been reported in only two case reports to date. A 28-year-old, oligomenorrheic female patient was admitted to the psychiatry department with symptoms of depression. The patient was diagnosed with major depression and bupropion 150mg/day was prescribed. After initiation of the treatment the patient experienced mild-to-moderate uterine bleeding, which resolved with discontinuation of the drug. In the patient's anamnesis, it was learned that the same side effect developed with the previous bupropion treatment. A comprehensive examination of the patient suggested that this adverse effect could strongly be associated with bupropion. This case supports the view that antidepressants can cause bleeding abnormalities, in particular vaginal bleeding caused by bupropion usage. Physicians who prescribe bupropion should carefully follow up their patients to identify such adverse effects.
Key words: Bupropion, abnormal uterine bleeding, adverse effect, case reports
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