Abstract

Paracetamol can cause a life threating renal damage and there is no specific treatment for it. Therefore, the current study aims to investigate the nepheroprotective effect of curcumin against paracetamol nephrotoxicity in rats through determination of kidney function parameters, minerals concentration, kidney lipid peroxidation and antioxidants. To achieve this aim, seventy adult male albino rats were divided into equal seven groups as following, Group I served as control,Group II (corn oil treated group), Group III (curcumin200 mg/kg b.wt/orally), Group IV (Curcumin 400 mg/kg b.wt/orally), Group V served as positive control (Paracetamol 500 mg/kg b.wt/orally), Group VI (Curcumin 200 mg/kg b.wt and paracetamol 500 mg/kg b.wt/orally), and Group VII (Curcumin 400 mg/kg b.w and paracetamol 500 mg/kg b.w/orally). At the end of experiment (after 30 days), blood and tissue samples were collected for biochemical, and histopathological analysis.

Key words: Renal toxicity, Curcumin, Paracetamol,Rats.