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Protective effect of dexpanthenol on gentamicin-induced nephrotoxicity in rats

Neslihan Pinar, Oguzhan Ozcan, Esin Dogan, Gokhan Cakirca.

Abstract
Aim: We evaluated the protective effects of dexpanthenol (Dxp) in rats with gentamicin (Genta)-induced nephrotoxicity by assessing a panel of biochemical and histopathologic parameters.
Material Methods: Forty rats were divided randomly into the following four groups: Control group, physiological saline solution (0.5 cc intraperitoneally (i.p.) for 8 days; Dxp group, Dxp (500 mg/kg i.p.) for 8 days; Genta group, Genta (100 mg/kg, i.p.) for 8 days; and Genta+Dxp group, Gent a and Dxp (100 and 500 mg/kg i.p., respectively) for 8 days.
Results: TIn the Genta group, the urea, creatinine, tumor necrosis factor-alpha (TNF-α), total oxidant status (TOS), oxidative stress index (OSI) and malondialdehyde (MDA) levels were significantly higher and the catalase (CAT) and glutathione peroxidase (GSH-Px) activities were significantly lower than those in the control group. In the Genta+Dxp group, the urea, creatinine, and TNF-α, TOS, OSI and MDA levels were significantly lower and the CAT and GSH-Px activities were significantly higher than those in the Genta group. Histopathological investigation showed severe tubular necrosis in the Genta group, which was of lesser severity in the Genta+Dxp group.
Conclusion: The biochemical and histopathologic results of this study indicate that Dxp can ameliorate Genta-induced nephrotoxicity.

Key words: Oxidative stress; antioxidant; gentamicin; nephrotoxicity; dexpanthenol.


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