Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles
 

Open Access

Original Article

J App Pharm Sci. 2020; 10(1): 101-107


Acetylcholinesterase: Inhibitory Activity of Some Indonesian Vegetables and Fraction of Selected Plants

Maulita Cut Nuria, Asep Gana Suganda, Elin Yulinah Sukandar, Muhamad Insanu.

Abstract
Dementia is a global health problem that requires severe treatment. People with dementia who consume vegetables everyday can reduce the risk of dementia. One type of diseases characterized by dementia is Alzheimer’s, which resulting in the decreased neurotransmitter acetylcholine. This study was to investigate the acetylcholinesterase enzyme (AChE) inhibitory activity of various vegetables which are widely used by Indonesian Sundanese and Javanese ethnics. In this study, total phenolic and flavonoid content were analyzed for determination of active compounds of the extracts. Ethanol extracts of 13 vegetables have been tested for AChE inhibitory activity using Ellman's colorimetric method in 96-well plate. Four types of extracts (Cosmos caudatus, Nasturtium officinale, Nothopanax fruticosus, and Ocimum americanum) had higher total phenolic and flavonoid content than other extracts. Vegetable extracts that had IC50 values less than 1000 µg/mL were C. caudatus and O. americanum. Both of these extracts were partitioned with n-hexane and water. The IC50 values of water fraction of C. caudatus and n-hexane fraction of O. americanum were 325.0±18.3 and 374.4±42.1 µg/mL, respectively. These result showed that fractions had a potential inhibitor of AChE and the chemical components (phenolic, flavonoid, and terpenoid) can be isolated to find the active compound.

Key words: Acetylcholinesterase, flavonoid, phenolic, vegetables



Similar Articles

Angiogenesis is Differentially Modulated by Anthocyanin and Phenolic Acid Extracts from Wild Blueberry () Through PI3K Pathway.
Tsakiroglou P, Weber J, Ashworth S, Del Bo' C, Klimis-Zacas D
Journal of medicinal food. 2021; 24(3): 226-235

Natural flavonoid morin showed anti-bacterial activity against Vibrio cholera after binding with cell division protein FtsA near ATP binding site.
Nag D, Dastidar DG, Chakrabarti G
Biochimica et biophysica acta. General subjects. 2021; (): 129931

(-)-Epicatechin-An Important Contributor to the Antioxidant Activity of Japanese Knotweed Rhizome Bark Extract as Determined by Antioxidant Activity-Guided Fractionation.
Jug U, Naumoska K, Vovk I
Antioxidants (Basel, Switzerland). 2021; 10(1):

Recent Advances in Metal-Phenolic Networks for Cancer Theranostics.
Zhang Z, Xie L, Ju Y, Dai Y
Small (Weinheim an der Bergstrasse, Germany). 2021; (): e2100314

Bioactive phenolic compounds from the flowers of (L.) Kitam. var. (Siebold et Zucc.) Kitam. (Asteraceae).
Devkota HP, Tsushiro K, Watanabe T
Natural product research. 2021; (): 1-4


Full-text options


Add your Article(s) to Indexes
• citeindex.org






ScopeMed.com
CiteIndex.org
CancerLine
FoodsLine
PhytoMedline
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.