Home|Journals|Articles by Year|Audio Abstracts

Original Research

Pharmacological and biological features of ethanol extract of Salvia virgata Jacq

Merve Ergul, Mehmet Atas, Halil Bal, Esra Ucar, Nuraniye Eruygur, Belgin Cosge Senkal, Tansu Uskutoglu.


Salvia virgata as an ethnomedicinal plant comprehends a variety of efficient active ingredients and shows diverse pharmacological actions, such as anti-proliferative, anti-inflammatory, and antimicrobial effects. In this study we aimed to determine the biological content of the ethanolic extract of S. virgata and to determine its possible pharmacological effects. The broth microdilution technique was carried out for determining antimicrobial activities, and the test microorganisms included E. coli, S. aureus, B. cereus, P. aeruginosa, C. albicans, and C. tropicalis. DPPH and ABTS methods were used to detect antioxidant activity. The XTT cell viability test was utilized to assess the antiproliferative activity of the ethanolic extract of S. virgata on L929 and MDA-MB-231 cell lines. S. virgata exhibited reasonable antimicrobial effects against E. coli (0.312 mg/mL) and S. aureus (0.312 mg/mL). DPPH and ABTS IC50 values were determined 291.58 ± 0.004 μg/mL, 16.74 ± 0.007 μg/mL respectively. S. virgata ethanolic extract TPC and TFC were observed 283.35 ± 10.4 mg GAE/g and 13.37 ± 1.6 mg QE/g, respectively. The extract was screened against α-amylase and α-glucosidase, AChE, and BChE enzymes, and inhibition activity was determined 75.73%, 62.72%, 67.19%, 3.18% respectively. The extracts did not significantly affect the L929 cell viability, while MDA-MB-231 remarkably reduced cell viability (IC50 = 0.118 mg/mL). The ethanolic extract of S. virgata can be considered as a potential therapeutic agent in the treatment of different pathological conditions due to its antimicrobial, antioxidant, and anticancer effects.

Key words: Salvia virgata extract; antimicrobial; antioxidant; enzyme inhibition; antiproliferative

Full-text options

Share this Article

Online Article Submission
• ejmanager.com

ejPort - eJManager.com
Refer & Earn
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.