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Histopathological alterations of submandibular salivary glands in Experimental Animal Albino Rat Induced by excess vitamin A

and Kadria Midhat EL kasheif.




Abstract
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Abstract Aim: The present work was designed to investigate the histopathological alterations in the submandibular salivary glands of the albino rat after induction high dose of vitamin A (hypervitaminosis A).
Methods: In this study, a total of 40male albino rats(120-150 grams body weight) were utilized. They were randomly divided into three groups. Group I, 10 animals were reserved as control group and was given sesame oil additionally to their food.
While, Group II and III (15 animals each) were administered vitamin A interperitoneally (500 IU/kg body weight/day/rat dissolve in sesame oil for 2and 3 weeks). Salivary glands were excised, weighed and fixed in10% phosphate buffered formalin (pH7.4) and stained with H&E stain. Histological examination of salivary gland was done using light microscopy.
Results: Group I showed normal acini, striated ducts and granular ducts. Whereas, group II and III showed atrophic changes in serous acini, loss of acinar architecture aswell as congestion of inter-acinar blood capillaries with more predominant alterations in group III as a result of increasing induction period.
Conclusion: The excessive intake of vitamin A more than recommended dosages as supplements or medications cause toxic effect and salivary gland alterations as a reflection of stress and injury.

Key words: Key Words: excess vitamin A, Albino Rat, Salivary glands, Histopathology.






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