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Original Article

ECB. 2014; 3(6): 543-547


SYNTHESIS AND NEUROTROPIC ACTIVITY OF NOVEL SULFOLANE-CONTAINING CAGE SULFONAMIDES

Iryna S. Zarovnaya, Helen T. Zlenko, Vitaliy A. Palchikov.



Abstract
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A novel water soluble cage sulfonamides was prepared and their neurotropic effects were evaluated. In vivo tests showed high level of
analgesic and tranquilizing activity of trans-N-(bicyclo[2.2.1]hept-5-en-endo-2-ylmethyl)-4-hydroxytetrahydrothiophene-3-sulfonamide1,1-dioxide, greater than well known sodium metamizole used as the internal standard. Stereochemical structure of the title compounds was
confirmed using the NOE and 2D NMR experiments.

Key words: sulfonamides; sulfolane; norbornene; adamantane; neurotropic activity; NOE experiments





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