Home|Journals|Articles by Year|Audio Abstracts
 

Original Article

ECB. 2014; 3(6): 543-547


SYNTHESIS AND NEUROTROPIC ACTIVITY OF NOVEL SULFOLANE-CONTAINING CAGE SULFONAMIDES

Iryna S. Zarovnaya, Helen T. Zlenko, Vitaliy A. Palchikov.




Abstract

A novel water soluble cage sulfonamides was prepared and their neurotropic effects were evaluated. In vivo tests showed high level of
analgesic and tranquilizing activity of trans-N-(bicyclo[2.2.1]hept-5-en-endo-2-ylmethyl)-4-hydroxytetrahydrothiophene-3-sulfonamide1,1-dioxide, greater than well known sodium metamizole used as the internal standard. Stereochemical structure of the title compounds was
confirmed using the NOE and 2D NMR experiments.

Key words: sulfonamides; sulfolane; norbornene; adamantane; neurotropic activity; NOE experiments






Full-text options


Share this Article


Online Article Submission
• ejmanager.com




ejPort - eJManager.com
Refer & Earn
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.