Abstract

Preeclampsia ranked second as the major causes in maternal death after hemorrhage in Indonesia. Elevated antiangiogenics factor such as soluble endoglin (sEng) andn soluble fms like tyrosine kinase-1 (sFit-1) and reduced proangiogenics such as vascular endothelial growth factor (VEGF), placental growth factor (P1GF), and transforming growth factor-β (TGF-β) have been documented in preeclampsia. Therefore, we aimed to conduct measurement of sEng and sFlt-1 level as early detection of preeclampsia. This was observational analytic study with cross sectional approach. Level of sEng and sFlt-1 was measured with high sensitivity indirect sandwich enzyme-linked immunosorbent assay (ELISA). Results showed that level of sEng and sFlt-1 were higher in severe preeclampsia compared to normal pregnancy. There was significantly positive correlation between level of sEng and sFlt-1 both in severe preeclampsia and normal pregnancy, in which higher sEng level was associated with higher sFlt-1 level.

Key words: Preeclampsia, sEng, sFlt-1