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Research Article

SRP. 2021; 12(1): 1598-1601

Correlation between Level of Soluble Endoglin and Soluble FMS-Like Tyrosine Kinase-1 on Severe Preeclampsia and Normal Pregnancy

Vaulinne Basyir, Prima Nanda Fauziah, Sofie R. Krisnadi, Anita Deborah Anwar, Yanwirasti, Johanes C. Mose, Fadil Oenzil.


Preeclampsia ranked second as the major causes in maternal death after hemorrhage in Indonesia. Elevated antiangiogenics factor such as soluble endoglin (sEng) andn soluble fms like tyrosine kinase-1 (sFit-1) and reduced proangiogenics such as vascular endothelial growth factor (VEGF), placental growth factor (P1GF), and transforming growth factor-β (TGF-β) have been documented in preeclampsia. Therefore, we aimed to conduct measurement of sEng and sFlt-1 level as early detection of preeclampsia. This was observational analytic study with cross sectional approach. Level of sEng and sFlt-1 was measured with high sensitivity indirect sandwich enzyme-linked immunosorbent assay (ELISA). Results showed that level of sEng and sFlt-1 were higher in severe preeclampsia compared to normal pregnancy. There was significantly positive correlation between level of sEng and sFlt-1 both in severe preeclampsia and normal pregnancy, in which higher sEng level was associated with higher sFlt-1 level.

Key words: Preeclampsia, sEng, sFlt-1

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