Home|Journals|Articles by Year|Audio Abstracts RSS - TOC
 

Research Article

SRP. 2021; 12(1): 1598-1601


Correlation between Level of Soluble Endoglin and Soluble FMS-Like Tyrosine Kinase-1 on Severe Preeclampsia and Normal Pregnancy

Vaulinne Basyir, Prima Nanda Fauziah, Sofie R. Krisnadi, Anita Deborah Anwar, Yanwirasti, Johanes C. Mose, Fadil Oenzil.




Abstract

Preeclampsia ranked second as the major causes in maternal death after hemorrhage in Indonesia. Elevated antiangiogenics factor such as soluble endoglin (sEng) andn soluble fms like tyrosine kinase-1 (sFit-1) and reduced proangiogenics such as vascular endothelial growth factor (VEGF), placental growth factor (P1GF), and transforming growth factor-β (TGF-β) have been documented in preeclampsia. Therefore, we aimed to conduct measurement of sEng and sFlt-1 level as early detection of preeclampsia. This was observational analytic study with cross sectional approach. Level of sEng and sFlt-1 was measured with high sensitivity indirect sandwich enzyme-linked immunosorbent assay (ELISA). Results showed that level of sEng and sFlt-1 were higher in severe preeclampsia compared to normal pregnancy. There was significantly positive correlation between level of sEng and sFlt-1 both in severe preeclampsia and normal pregnancy, in which higher sEng level was associated with higher sFlt-1 level.

Key words: Preeclampsia, sEng, sFlt-1






Full-text options


Share this Article



Online Article Submission
• ejmanager.com
• ojshosting.net




eJManager.com
Review(er)s Central
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.