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Research Article

SRP. 2021; 12(1): 1594-1597

Anti-angiogenic Effect of Black Rice Bran (Oryza Sativa L. ‘Sembada Hitam’) on Soluble Fms-Like Tyrosine Kinase and Placental Growth Factor in Preeclampsia

David Randel Christanto, Johanes C. Mose, Tetty Yuniarti, Muhammad Begawan Bestari, Prima Nanda Fauziah, Yekti Asih Purwestri, Jefferson N. Munthe.


Preeclampsia is a multisystem disorder of pregnancy that contributes to morbidity and mortality worldwide. Soluble FMS-like tyrosine kinase-1 (sFlt-1) is considered as an etiologic factor of endothelial damage in preeclampsia. Imbalance of sFlt-1 and PlGF could cause failure in trophoblastic invasion and physiological remodeling of spiral artery, and ultimately placental hypoxia. This study aimed to observe anti-angiogenic properties of black rice bran on preeclampsia through measurement of sFlt-1 and PIGF. Serum was collected from pregnant women at 28-34 weeks of gestational age with preeclampsia, and normal preeclampsia as control. Level sflt-1 and PGIF was quantified with enzyme linked immunosorbent assay (ELISA). Absorbance was read at 450 nm wavelength. Extract of black rice bran has anti-angiogenic properties by significantly decreasing sFlt-1 as well as increasing PIGF in preeclampsia-induced HUVEC. This makes black rice bran a promising agent which can be further used in preeclampsia treatment.

Key words: Black rice bran, placental hypoxia, preeclampsia, PlGF, sFlt-1

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