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The Management Growth Plate Injury in Animal Studies with Stem Cells Technique: Systematic Review

Panji Sananta, Yun Isnansyah, Rizqi D Rosandi, Muhammad Alwy Sugiarto.


Background: Injury of growth plate may lead to serious complications such as bone bridge formation, deformity, growth disturbance, and limb length discrepancy. Stem cell therapy is one of the fields studied to mitigate this problem. There are various types and techniques which can be implemented. Objective: This systematic review aims to review the most common techniques used in the experimental animal study about the application of stem cells to treat growth plate injury. Methods: This study was conducted according to PRISMA guidelines. The following strategy was used. The terms used on the search engine were “stem cell growth plate injury” in PubMed database. A bibliometric evaluation was done on all the search results. Results: The initial PubMed search yielded 74 results, but 5 articles were eliminated because they could not be accessed. From the remaining 69 articles, 50 were excluded after abstract and full-text review. Further, 7 articles were eliminated because they did not meet the inclusion criteria. Most studies are experimental animal studies, and there is no human trial regarding this matter. Conclusion: There are still a few studies evaluating the application of stem cell in treating growth plate injuries, but the present results are generally satisfactory. Hopefully, clinical trials could be conducted in the near future.

Key words: Animal experimental study, Growth plate, Stem cell, Injury, Systematic Review

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