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Original Article

ECB. 2014; 3(5): 460-462


GREEN SYNTHESIS OF NOVEL PHTHALIMIDE DERIVATIVES OF P-AMINOSALICYLIC ACID AS POTENTIAL ANTITUBERCULOSIS AGENTS

Y. Dathu Reddy, P. Praveen Kumar, B. Rama Devi, Ch. Venkata Ramana Reddy, P. K. Dubey.




Abstract

Green synthesis of novel compounds 4-(2-carboxybenzamido)-2-hydroxybenzoic acids 3a-3e and 4-(1,3-dioxoisoindolin-2-yl)-2-hydroxybenzoic acids 4a-4e have been developed in good yields which were analogues of p-aminosalicylic acid (used as anti-tuberculosis agent).

Key words: phthalic anhydrides; p-aminosalicylic acid; anti-tuberculosis agents; 4-(2-carboxybenzamido)-2-hydroxybenzoic acids; 4-(1,3-dioxoisoindolin-2-yl)-2-hydroxybenzoic acids






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