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Original Article

Open Vet J. 2022; 12(3): 407-413

Adjustment of multi-leaf collimator parameters in 4-MV and 6-MV IMRT: A study of veterinary clinical cases

Toshie Iseri,Yoshinori Tanabe,Hiro Horikirizono,Hiroshi Sunahara,Harumichi Itoh,Yuki Nemoto,Kazuhito Itamoto,Kenji Tani,Hidekazu Tanaka,Munekazu Nakaichi.

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Background: For optimal treatment, it is important to maintain optimal multi-leaf collimator (MLC) transmission in intensity-modulated radiation therapy (IMRT). However, adjustment of transmissions has not been reported in veterinary medicine.
Aim: This study aimed to demonstrate that appropriate MLC parameter adjustment for IMRT using 4- and 6-MV energy can reduce the need for quality assurance revalidation in real companion animal clinical cases.
Methods: The MLC parameters (leaf transmission and leaf offset) of the treatment planning system were adjusted by evaluating seven plans (10 × 10 cm, 3ABUT, DMLC, 7segA, FOURL, HDMLC, and HIMRT) and 20 pre-clinical cases (10 cases each in 4 and 6 MV groups). Subsequently, 101 IMRT plans of 88 cases (77 dogs and 11 cats) were evaluated for absolute dose of plan target volume (PTV) and organs at risk (OAR) and were analyzed for the relative dose distribution by gamma analysis (3%/3 mm, >10%) using EBT3 film.
Results: After adjustment of the MLC parameters (leaf transmission and leaf offset, 4 MV: 0.008 and 0, 6 MV: 0.005 and 0), the data from 101 plans (4MV: 64 plans and 6MV: 37 plans) treated with IMRT showed PTV

Key words: IMRT, Linac, MLC offset, MLC transmission, Radiation therapy

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