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Int Med. 2019; 1(5): 280-285

Relationship of mutation in adhesion molecules and cytokeratins with hair follicle diseases

Laura Silva, Ricardo Hsieh, Ricardo Romiti, Alessandra Anzai, Bruno Rocha, Silvia Lourenço, Neusa Valente, Juliana Fernandes.


Adhesion molecules and cytokeratins are essential for the development of hair follicles and their maintenance. These molecules seem to be responsible for the follicular germ downgrowth and signaling with mesenchymal cells for the correct development of hair follicles. In adulthood, changes in their functions are related to numerous pathologies that lead to hair shaft disorders and cicatricial and non-cicatricial alopecia. This work reviews the main adhesion molecules: cadherins, integrins and cytokeratins and their relationship with hair follicle pathologies.

Key words: cytokeratin, hair diseases, hair follicle, monilethrix, vascular cell adhesion molecule

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