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Original Article

β-Caryophyllene causes remyelination and modifies cytokines expression in C57BL/6 mice with Experimental Autoimmune Encephalomyelitis

Harleson Lopes Mesquita,Livia Almeida Fontes,Laetitia Cinsa,Ademar Alves da Silva Filho,Akinori Nagato,Beatriz Julião Aarestrup,José Otávio do Amaral Corrêa,Fernando Monteiro Aarestrup.

Cited by 3 Articles

Objectives: To evaluate the effect of β-Caryophyllene (BCP) on the production of IL-17, transcription factors (T-bet, GATA-3) and remyellination in C57BL/6 mice induced for experimental autoimmune encephalomyelitis (EAE), the model for studying pathogenesis and new therapies for multiple sclerosis (MS). Materials and methods: EAE was induced in three groups of C57BL/6, with administration of BCP in two groups (25 and 50 mg/kg/day) by gavage, after the tenth day of induction. At nine days of treatment, mice were euthanized and CNS was removed for the analysis. The profiles of IL-17, T-bet, GATA-3 and the possible remyelination properties were investigated in the central nervous system (CNS) by immunohistochemistry and Weigert-Pal-Russel’s method, respectively. Results: BCP group (50 mg/kg/day) showed a reduction of IL-17 in brain, cerebellum and medulla (p

Key words: β-Caryophyllene, multiple sclerosis, experimental autoimmune encephalomyelitis

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