Objectives: To evaluate the effect of β-Caryophyllene (BCP) on the production of IL-17, transcription factors (T-bet, GATA-3) and remyellination in C57BL/6 mice induced for experimental autoimmune encephalomyelitis (EAE), the model for studying pathogenesis and new therapies for multiple sclerosis (MS). Materials and methods: EAE was induced in three groups of C57BL/6, with administration of BCP in two groups (25 and 50 mg/kg/day) by gavage, after the tenth day of induction. At nine days of treatment, mice were euthanized and CNS was removed for the analysis. The profiles of IL-17, T-bet, GATA-3 and the possible remyelination properties were investigated in the central nervous system (CNS) by immunohistochemistry and Weigert-Pal-Russels method, respectively. Results: BCP group (50 mg/kg/day) showed a reduction of IL-17 in brain, cerebellum and medulla (p
Key words: β-Caryophyllene, multiple sclerosis, experimental autoimmune encephalomyelitis
|
