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β-Caryophyllene causes remyelination and modifies cytokines expression in C57BL/6 mice with Experimental Autoimmune Encephalomyelitis

Harleson Lopes Mesquita, Livia Beatriz Almeida Fontes, Laetitia Alves Cinsa, Ademar Alves Da Silva Filho, Akinori Cardozo Nagato, Beatriz Julião Vieira Aarestrup, José Otávio do Amaral Corrêa, Fernando Monteiro Aarestrup.

Abstract
Objectives: To evaluate the effect of β-Caryophyllene (BCP) on the production of IL-17, transcription factors (T-bet, GATA-3) and remyellination in C57BL/6 mice induced for experimental autoimmune encephalomyelitis (EAE), the model for studying pathogenesis and new therapies for multiple sclerosis (MS). Materials and methods: EAE was induced in three groups of C57BL/6, with administration of BCP in two groups (25 and 50 mg/kg/day) by gavage, after the tenth day of induction. At nine days of treatment, mice were euthanized and CNS was removed for the analysis. The profiles of IL-17, T-bet, GATA-3 and the possible remyelination properties were investigated in the central nervous system (CNS) by immunohistochemistry and Weigert-Pal-Russel’s method, respectively. Results: BCP group (50 mg/kg/day) showed a reduction of IL-17 in brain, cerebellum and medulla (p

Key words: β-Caryophyllene, multiple sclerosis, experimental autoimmune encephalomyelitis



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