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Original Research

RMJ. 2023; 48(1): 265-268


Protective effects of Curcuma Longa (Turmeric) on methotrexate induced congestion in portal vein in the liver of albino mice

Farah Deeba, Shehla Khatoon, Ronaq Zaman, Fatima Daud, Sadia Shaukat, Tahira Mehreen.




Abstract

Objective: To observe the protective effects of turmeric against methotrexate induced hepatotoxicity.
Methodology: This experimental study included 28 adult male albino mice which were divided into control Group A and experimental Groups, B, C and D. In control Group A, 4 mice, and in Group B, C and D 8 mice were included. To group A, no drug was given. Turmeric extract per oral (400mg /kg) daily was given to Group B for 14 days. Injection methotrexate (40mg/kg) intraperitoneal (I.P) was given to Group C on day 7. Turmeric extract per oral (400mg /kg) daily for 7 days was given to Group D as pre administration to injection methotrexate and on day 7 injection methotrexate (40mg/kg) was given intraperitoneally (I.P) and turmeric extract per oral (400mg/kg) was given for further 7 days daily, post administration to injection methotrexate. All the animals were dissected on day 14 and liver was examined under light microscope to study histological parameters.
Results: The histological examination of liver sections of group A (control) showed normal appearance of portal vein. In Group B (turmeric treated group), no obvious histological changes were observed. Examination of liver tissue of Group C (methotrexate group) showed severe histological changes, which included congestion of portal vein. Group D (methotrexate +turmeric group) showed significant reduction in congestion of portal vein.
Conclusion: This study clearly demonstrates that administration of turmeric (Curcuma Longa) protects liver tissue.

Key words: Turmeric, methotrexate, liver damage, congestion in portal vein, antioxidant.






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