Home|Journals|Articles by Year|Audio Abstracts
 

Original Article



Brucyclin, a novel antimicrobial peptide structurally designed from the antibacterial plant peptide, Brucin

Thakorn Sornwatana, Nuanchawee Wetprasit, Somchoke Traewachiwiphak, Thanawat Phongsak, Sittiruk Roytrakul.




Abstract
Cited by 0 Articles

A novel antimicrobial cyclic peptide, Brucyclin, was rationally designed from the original antibacterial plant peptide, Brucin. The chemically synthesized Brucyclin consists of amino acid sequence; (NH2- Gln-His-Thr-Leu-Cys-Met-Cys-Gly-Gly-Ala-Thr-Trp-COOH), with a molecular mass of m/z 1290. In the antimicrobial assay with 31 strains of pathogenic microorganisms, the peptide exhibited the most antimicrobial activity with a minimum inhibitory concentration (MIC) values ranging from 50-100 μg/ml against 2 strains of Gram-negative bacteria (Vibrio cholera non O1, non O139 and Klebsiella oxytoca), 1 strain of Gram-positive bacterium (Bacillus subtilis), and 1strain of yeast (Candida albicans), respectively. Structural analysis of Brucyclin indicated that it has a neutral charge with a hydrophobicity ratio of 50% and pI value of 6.72, respectively. The results from this study suggested that Brucyclin is a new antibiotic peptide that might be an alternative potent drug for treatment of various infectious diseases caused by pathogenic microorganisms.

Key words: antibacterial activity, antimicrobial peptide, Brucin, Brucyclin, cyclic peptide






Full-text options


Share this Article


Online Article Submission
• ejmanager.com




ejPort - eJManager.com
Refer & Earn
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.