Home|Journals|Articles by Year|Audio Abstracts
 

Original Article



Synthesis and antibacterial evaluation of new azo-pyrmidine derivatives

Mohamed A Abdelgawad.




Abstract
Cited by 6 Articles

The synthesis of potent antibacterial agents, free from side effects and resistant to bacterial enzymes, is the main objective for drug designers. Also, the multi-target drugs have important role in advanced drug synthesis. The azo-malonate compounds II a &b were prepared from diazo coupling reaction of aniline derivatives with the acidic methylene group of diethyl malonate. The new azo-malonate derivatives IIa-c were reacted with urea or thiourea in presence of sodium ethoxide, afforded the target new azo-pyrimidine compounds IIIa&b and IV a &b. The structure of the new compounds was elucidated by using NMR, IR, mass spectroscopy and elemental analysis. The MIC of new azo-compounds IIIa&b and IVa&b was evaluated for their antibacterial activity. Two new synthesized compounds showed weak (IIIb) to strong (IVb) antibacterial activity. The MOE docking program was used for prediction of the compound IVb action mechanism.

Key words: Antibacterial; Pyrimidine; Diethyl Malonate; Pyrimidinone






Full-text options


Share this Article


Online Article Submission
• ejmanager.com




ejPort - eJManager.com
Refer & Earn
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.