Ten new chalcones were prepared in three steps, firstly phthalic anhydride reacted with 4- amino acetophenone to produce 2-(4-acetyl phenyl carbamoyl) benzoic acid (M1), secondly [2-(4-acetyl phenyl carbamoyl) benzoic acid (M1)] suffers from the loss of a water molecule via reaction with (anhydrous sodium acetate and acetic anhydride) to produce 2-(4-acetyl phenyl) isoindoline-1,3-dione (M2), thirdly (M2) condensed with various substituted benzaldehydes affording chalcones (M3- M12) were reacted with 2-aminophenol to produce 1, 5- benzooxazepines compounds (M13- M22).
The prepared compounds were characterized by determination of melting point, FT-IR and some of the prepared compounds have been characterized by (1H-NMR and 13C-NMR) techniques, the antibacterial activity of some of the compounds have also been evaluated.
Key words: Chalcones, Benzoxazepines, phenylcarbamoyl, antibacterial
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