Abstract

This study was carried out to determine the phytochemical constituents of Anogeissus leiocarpus and its acute toxicity (LD50) in wistar rats. The phytochemical analysis was carried out using acetone as solvent andthe acute toxicity studyusing Lorke’s method.Twelve (12) adult rats weighing 180-230g body weight were used. The rats were divided into 3 groups of 3 rats each in phase 1, and 1 rat each in phase 2, respectively. The extract was administered to the rats orally at concentrations10mg/kg, 100mg/kg and 1000mg/kg in phase 1. In phase 2, the rats were given the extract at concentrations of 140mg/kg, 225mg/kg and 600mg/kg. Signs of toxicity were observed within 24 hours in both phase 1and 2. Also, mortality was observed only in group 3 of phase 1 where all the rats died. Based on this study, it can be concluded that the leaves of this plant should be used with caution for medicinal purposes.

Key words: Acute toxicity, Anogeissus leiocarpus, Acetone, Phytochemical analysis