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Preliminary evaluation of hepatoprotective and nephroprotective effects of Prosopis ruscifolia Griseb. leaves extract in mice

María S. Soverina, Miguel A. Campuzano-Bublitz, Juan R. Centurión, Antonia K. Galeano, María L. Kennedy.

Abstract
Liver and kidney are vital organs for body homeostasis, and are exposed to damage or injury of various origins. Many medicinal plants have proved to be effective for hepatic and renal diseases. This study aimed to test the effect of Prosopis ruscifolia leaves extract on acetaminophen induced hepatotoxicity and gentamicin induced nephrotoxicity. The experiment was carried out in mice, 300mg/kg of acetaminophen, i.p., and 135mg/kg of gentamicin were used to induce liver and kidney damage, respectively. Silymarin was used as protective control drug. For estimating the liver function alkaline phosphatase (ALP), aspartate aminotransferase (AST o GOT) and alanine aminotransferase (ALT o GPT) were measured; and creatinine, urea and uric acid were determined in order to verify kidney functionality. The results showed that the extract has both, hepatoprotective and nephroprotective effect, evidenced by reduced values of GOT, GPT and ALP, in mice co-administered, p.o., with P. ruscifolia; and by the reduction of serum creatinine in mice with gentamicin induced kidney damage, when these animals were treated with the extract, and the values were compared with pathological group. The alcoholic extract of P. ruscifolia denoted hepatoprotective and nephroprotective effects.

Key words: Prosopis ruscifolia, gentamicin, acetaminophen, mice, transaminases, creatinine



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