Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access

Original Research

Ann Med Res. 2019; 26(10): 2098-104

The impact of systemic inflammatory markers on survival in metastatic gastric cancer patients receiving first-line chemotherapy

Oktay Bozkurt, Sedat Tarik Firat, Ender Dogan, Ramazan Cosar, Mevlude Inanc, Metin Ozkan.

Aim: The prognostic impact of elevated systemic inflammatory tools, including the neutrophil-lymphocyte ratio (NLR) and the platelet-lymphocyte ratio (PLR), remains moot in cancer patients. This research was performed to explore the predictive worth of these markers for prognoses in metastatic gastric cancer (mGC) patients receiving chemotherapy.
Material and Methods: We retrospectively appraised 158 patients diagnosed with mGC between February 2009 and November 2017. According to threshold values that were identified by receiver operating characteristic (ROC) curve analysis, the NLR and PLR were each divided into two groups: ≤ 2.11 and >2.11, ≤ 158.8, and >158.8, respectively. The Cox proportional hazards model was applied to uncover the probable predictors of progression-free survival (PFS) and overall survival (OS).
Results: According to univariate analysis, poor performance status, high NLR, high PLR, and anemia were significantly correlated with inferior OS receiving first-line palliative chemotherapy. High NLR, high PLR, and anemia were significantly correlated with poor PFS. In the multiple analysis, an elevated NLR was identified to be an independent predictor of inferior OS (OR: 2.70, 95% CI: 1.75-4.16, p

Key words: Metastatic gastric cancer; neutrophil to lymphocyte ratio; platelet-to-lymphocyte ratio; prognosis.

Similar Articles

Disparities in Genetic Testing for Heritable Solid-Tumor Malignancies.
Dillon J, Ademuyiwa FO, Barrett M, Moss HA, Wignall E, Menendez C, Hughes KS, Plichta JK
Surgical oncology clinics of North America. 2022; 31(1): 109-126

Generating Monocyte-Derived Endothelial-like Cells for Vascular Regeneration.
Smith RJ, Andreadis ST
Methods in molecular biology (Clifton, N.J.). 2022; 2375(): 13-19

Financial Toxicity and Shared Decision Making in Oncology.
Greenup RA
Surgical oncology clinics of North America. 2022; 31(1): 1-7

Epsin 3 potentiates the NF‑κB signaling pathway to regulate apoptosis in breast cancer.
Wu Q, Li Q, Zhu W, Zhang X, Li H
Molecular medicine reports. 2022; 25(1):

Organelle-inspired supramolecular nanomedicine to precisely abolish liver tumor growth and metastasis.
Zhan J, Wang Y, Ma S, Qin Q, Wang L, Cai Y, Yang Z
Bioactive materials. 2022; 9(): 120-133

Full-text options

Latest Statistics about COVID-19
• pubstat.org

Add your Article(s) to Indexes
• citeindex.org

Covid-19 Trends and Statistics
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.

ScopeMed Web Sites