Background: Some members of the genus Phyllanthus have been widely used in global traditional medicine to manage a variety of liver diseases and experimentally documented to have hepatoprotective activity. However, it is not known whether Phyllanthus pentandrus (PP) (a member of the genus endogenous to Northwestern Nigeria) possesses hepatoprotective properties.
Aims and Objective: The objective was to investigate the hepatoprotective and body weight lowering effects of the aqueous leaf extract of PP using a high-fat diet (HFD)-induced rat model of nonalcoholic fatty liver disease (NAFLD).
Materials and Methods: After obtaining ethical permission from a departmental committee, Wistar rats were randomly assigned to one of the following treatments for 7 weeks: vehicle + normal diet, vehicle + HFD, orlistat + HFD (at 400 mg/1000 g of HFD), or the PP extract +HFD (500 mg/100 g of HFD). Serum levels of liver enzymes (alkaline phosphatase [ALP], aspartate transaminase [AST], and alanine transaminase), conjugated and total bilirubin were determined. Determination of final body weight gain, adipose tissue weight, liver weight, as well as liver histology, was also performed on the animals.
Results: Compared with normal controls, HFD-fed rats exhibited a significant elevation in ALP, severe liver steatosis, body weight gain, and increased adipose tissue mass. Treatment with the PP extract prevented the increase in the level of ALP, reduced the serum level of AST and ameliorated the hepatic steatosis, and adipose tissue gain.
Conclusion: These findings suggest that PP may be beneficial in the management of NAFLD commonly associated with obesity.
Phyllanthus pentandrus; Fatty Liver; High-Fat Diet; Rats
Brain functional remodeling caused by sciatic nerve transposition repair in rats identified by multiple-model resting-state blood oxygenation level-dependent functional magnetic resonance imaging analysis.
Yuan YS, Xu HL, Liu ZD, Kou YH, Jin B, Zhang PX
Neural regeneration research. 2022; 17(2): 418-426
High-frequency spinal cord stimulation produces long-lasting analgesic effects by restoring lysosomal function and autophagic flux in the spinal dorsal horn.
Wang ZB, Liu YD, Wang S, Zhao P
Neural regeneration research. 2022; 17(2): 370-377
Clinical features and development of Sepsis in Klebsiella pneumoniae infected liver abscess patients: a retrospective analysis of 135 cases.
Li S, Yu S, Peng M, Qin J, Xu C, Qian J, He M, Zhou P
BMC infectious diseases. 2021; 21(1): 597
coinfection as source of pyogenic liver abscess.
Burch J, Tatineni S, Enofe I, Laird-Fick H
BMJ case reports. 2021; 14(5):
ATCC 4356 Exopolysaccharides Suppresses Mediators of Inflammation through the Inhibition of TLR2/STAT-3/P38-MAPK Pathway in DEN-Induced Hepatocarcinogenesis in Rats.
Khedr OMS, El-Sonbaty SM, Moawed FSM, Kandil EI, Abdel-Maksoud BE
Nutrition and cancer. 2021; (): 1-11