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Research Article

ECB. 2021; 10(4): 242-256


MOLECULAR DOCKING STUDIES of VARIOUS PHYTOCONSTITUENTS from TINOSPORA CORDIFOLIA on VARIOUS ANTIOBESITY TARGET

Prasad T., Mahapatra A., Sharma T..


Abstract

Tinospora cordifolia (TC) is an indigenous species of family Menispermaceae found in different regions of the Indian subcontinent. Molecular docking analysis has been done to study the antiobesity activity of nineteen phytoconstituents from TC against six targets of obesity like leptin, pancreatic lipase, fat and obesity protein, SCH1Protein, human cannabinoid receptor, MCH1 receptor and Gherlin. The data of this analysis has been detailed in the article. The proteins were downloaded from the RCSB protein data bank and the structures of the phytoconstituents were collected from PubChem. The docking study was conducted using PyRx software and visualization was carried out using BIOVIA discovery studio visualizer. The docking score and the amino acid interactions were analyzed and compared to the standard marketed drug, Orlistat. The results concluded that the best interacting ligand, i.e., Tinosporin C can be explored further for the development novel antiobesity agent.

Key words: Antiobesity; Leptin; Molecular docking; Orlistat; Phytochemical; Tinospora Cordifolia






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