Herein we have reported a simple, rapid and efficient synthesis of 7-(substituted phenyl)-5-(1H-imidazol-4-yl)-5,8-dihydro-[1,2,4]triazolo[4,3-a]pyrimidine derivatives. In the present study, PEG-400 was used as an alternative and green reaction solvent in the first step and n-butanol in the second step. The protocol proposed in this work offers advantages, such as common starting materials, simple work-up, shorter reaction time, high yield and absence of the catalyst. The structural elucidation of these compounds is based on mass, IR, 1H NMR and 13C NMR spectral data. All the synthesized compounds have been evaluated for their in vitro antimicrobial and antitubercular activity.
Key words: Absence of catalyst; Antitubercular activity; Imidazole; Pyrimidine; Triazole
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