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Research Article

JCDR. 2021; 12(6): 1049-1055

Thyroid Function Abnormalities in Patients with Chronic Kidney Disease - A Prospective Study from North India

Dr.Anirban Bhaumik,Dr.Harinder Kumar, Dr Amit Johari, Dr.Atindra Narayan, Dr. Rajesh Ranjan, Dr. P. S. Nayyer.


Background:Chronic kidney disease (CKD) is a common disorder that has a variety of
health effects. Hypothyroidism have substantial clinical implications for the CKD population
if there is a molecular relationship between hypothyroidism and CKD, so this study was
conducted with an aim to estimate the prevalence of hypothyroidism in CKD patients in
Delhi and to explore the correlation between hypothyroidism and severity of renal
diseases.Material and Methods:The present cross-sectional observational study was
conducted among patients with CKD attending OPD or admitted at Dr. Baba
SahebAmbedkar Medical College and Hospital. The blood was collected after 10 to 12 hours
of fasting. For thyroid profile [serum free tri-iodothyronine (FT3), serum free thyroxine
(FT4) and serum thyroid stimulating hormone (TSH)] blood sample was collected in nonheparinized
serum bottle. The data was coded and entered into Microsoft Excel spreadsheet
and during data analysis, level of significance was set at P≤0.05.Results:In present study one
third of subjects (33.0%) belonged to 50-60 years of age group. Majority of study subjects
were males (72.0%). Among 46.0% subjects the TSH was raised above normal value and
24.0% of subjects were having subclinical hypothyroidism. During ANOVA analysis, the
levels of serum creatinine were significantly raised (p=0.01) in subjects with overt,
subclinical hypothyroidism and Low T3 when compared to euthyroid
subjects.Conclusion:From our study, we conclude that hypothyroidism were correlated with
severity of renal diseases and patients with severe hypothyroidism have more severe renal
diseases. We also suggest a prospective study that provide a more accurate picture of the true
prevalence of hypothyroidism in the CKD population is desirable.

Key words: Chronic Kidney Disease, Hypothyroidism, Renal Disease

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