Early diagnostic marker for the conversion of asymptomatic to symptomatic visceral leishmaniasis

Roshan Kamal Topno; Rajeev Kumar; Krishna Pandey; Manas Ranjan Dikhit; Major Madhukar; Maneesh Kumar; Sanjiva Bimal; Niyamat Ali Siddiqui; Vidyanand Ravi Das; Kanhaiya Agrawal; Neena Verma; Chandra Shekhar Lal; Pradeep Das

doi:10.5455/jmas.52041

J Med Allied Sci. 2019; 9(2): 96-99

doi: 10.5455/jmas.52041

Early diagnostic marker for the conversion of asymptomatic to symptomatic visceral leishmaniasis

Roshan Kamal Topno, Rajeev Kumar, Krishna Pandey, Manas Ranjan Dikhit, Major Madhukar, Maneesh Kumar, Sanjiva Bimal, Niyamat Ali Siddiqui, Vidyanand Ravi Das, Kanhaiya Agrawal, Neena Verma, Chandra Shekhar Lal, Pradeep Das.

Abstract
The study was carried out on 1104 people of visceral leishmaniasis (VL) endemic region to detect the suitable marker in asymptomatic individuals that illustrate as a marker for conversion in symptomatic VL subject. In this study, 46 individuals (asymptomatic) with rK39 strip test positive without any previous VL sign and symptoms were later found symptomatic. Hematological and immunological investigations illustrated the lower hemoglobin (g/dl) and increase in interleukin-10 (IL-10) respectively from normal range which would be the primary markers in the asymptomatic individuals that might convert to symptomatic VL. Key words: Asymptomatic, Hematological marker, Immunological marker, Leishmaniasis

Early diagnostic marker for the conversion of asymptomatic to symptomatic visceral leishmaniasis

Abstract