The present study aimed to formulate a mucoadhesive in-situ gel with mucilage extracted from Corchours olitorius for the intranasal route. Propranolol HCL used as a model drug. For the comparative study, the mucoadhesive in-situ gels were prepared using two different concentration 0.4% and 0.5% of Corchours olitorius mucilage, Carbopol P-934 and HPMC (hydroxypropyl methylcellulose). The prepared in-situ gel was subjected to characterization test such as pH, appearance, gelation temperature, spreadability, viscosity, mucoadhesive strength, In-vitro study. Form the comparative study, 0.5% mucilage containing in situ gel formulation can be considered as optimum formulation.
Key words: Mucilage, Mucoadhesive, In-situ gel, Intranasal administration
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