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Original Research

RMJ. 2022; 47(1): 30-33


Serum melanin and alpha-melanocyte stimulating hormone (α-MSH) levels in Pakistani individuals affected with oculocutaneous albinism

Muhammad Shakil, Kaukab Sultana, Rana Naveed Iqbal, Muhammad Ikram Ullah, Shabbir Hussain, Saqib Mahmood.




Abstract

Objective: To determine the serum levels of melanin, α-MSH, and to find their association and correlation in patients with Oculocutaneous albinism (OCA).
Methodology: This study included 80 subjects; 40 OCA patients and 40 healthy controls. ELISA was performed to determine the serum concentrations of melanin and α-MSH.
Results: Serum melanin level of 6.0 ng/dL was significantly reduced and serum levels of α-MSH of 9.8 ng/dL was significantly higher (p

Key words: Oculocutaneous albinism (OCA), melanin, alpha-melanocyte stimulating hormone (α-MSH), Pakistan.






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