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Original Research

RMJ. 2020; 45(1): 22-26


Urinary tract pathogens and their patterns of resistance to commonly used antibiotics

Salman Farooq Dar, Malik Muhammad Atif, Muhammad Hamza Arshad, Muhammad Fahr Hayat, Talha Farooq Dar.




Abstract

Objective: To evaluate the prevalence of certain microorganisms in urine and their antibiotic sensitivities.
Methodology: This retrospective descriptive study was done collecting data from records of Chughtai Lab between May 2016 and March 2018 from their branch near Mayo Hospital, Lahore. By convenience sampling, only those 290 out of total 722 reports of urine culture and sensitivity were included, which yielded at least one microorganism. All age groups and genders were included. All negative reports were excluded.
Results: Mean age of patients was 59.49years (range 1-90). A total of 290 reports yielded 319 microorganisms among which 29 reports showed two organisms each. Candida spp. co-existed in 26 cases. E.coli was found to be the most prevalent organism; 181/319 (56.74%), followed by Enterococcus faecalis; 58/319 (18.18%). Most active antibiotics against gram positive organisms were; Linezolid (100%, n=58), Doxycycline (96.55%, n=58), Vancomycin (91.22%, n=57) and Nitrofurantoin (70.68%). Most efficient antibiotics against gram negative organisms were; Fosfomycin (90.91%, n=198), Carbapenems i.e. Imipenem and Meropenem (89.19%, n=259), Amikacin (85.6%, n=250), Cefoperazone plus Sulbactam (81.62%, n=234), Piperacillin plus Tazobactam (80.54%, n=257) and Nitrofurantoin (72.88%).
Conclusion: E.coli was the most prevalent organism and Fosfomycin and Carbapenems were most effective antibiotics. Fluoroquinolones didn’t appear to be a good choice for treatment of UTIs.

Key words: Antibiotics, Antibiotic Prophylaxis, Antimicrobial Drug Resistance, Bacteriuria, Cystitis, Gram Negative Bacteria, Gram Positive Bacteria, Pyelonephritis, Urethritis, Urinary Tract Infections.






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