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Research Article

SRP. 2021; 12(1): 1375-1380

Early Onset Sepsis Risk Calculator and Vitamin D Level in Newborn Exposed to Premature Rupture of Membranes

Helmy AS, ELMeneza SA, ELBagoury IM.

Background: Neonatal sepsis is an important cause of morbidity and mortality.
Aim of work: Study the diagnostic value of early-onset sepsis risk calculator (EOSR) and vitamin D as markers for early diagnosis of sepsis among the newborn infants > 34 weeks who were exposed to premature rupture of membrane (PROM).
Patients and Methods: This observational case-control study included 100 newborn infants > 34 weeks of gestation. Newborn infants were assigned into two groups according to the development of sepsis and exposure to PROM: septic and control groups. Kaiser EOSR calculator was used. Vitamin D was estimated by ELISA.
Results: There was a significant increase of EOSR calculator mean values in the septic group than the control group at birth and after clinical examination. The median ± IQR was 10.26 (5.3-24) per 1000/birth at birth in the sepsis group and 0.47(0.39 – 0.67) in the control group. EOSR calculator was 63.2 (25.5 – 142.6) per 1000/births after clinical examination in the septic group and 0.19(0.16 – 0.27) in the control group, P-value was < 0. 001. There was a significant decrease in vitamin D in the septic group (8.57 ± 9.14 ngL) than the control group (50.61 ± 12.55ngL), the P-value was 34 weeks of gestation. Estimation of vitamin D in neonates with equivocal EOSR calculator score may assist in the early management.

Key words: Premature rupture of membrane -Early Onset Sepsis Risk Calculator - Vitamin D –Full-term infants –Near term infants - Early-onset neonatal sepsis

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