|JCDR. 2022; 13(1): 115-120
To study the effect of single dose dexmedetomidine given prior to extubation on extubation conditions in adult patients following general
anaesthesiaSwati Trivedi, Vivek Tyagi, Neha Sharma.
Aim:To study the effect of single dose dexmedetomidine given prior to extubation on
extubation conditions in adult patients following general anaesthesia.
Material and methods: This prospective, randomized, study was carried out in the
Department of Anaesthesiology.After obtaining informed written consent for participation in
the study, 50 adult patients aged 18-70 years belonging to American Society of
Anaesthesiologists physical status (ASA PS) class I-II of both genders undergoing elective
surgeries were enrolled.
Results: Incidence of cough at extubation was comparable in both groups (68% vs. 66%, p
1.20). Baseline mean arterial pressure was comparable in both groups, but at 3min after
extubation it was significantly lower in Group A. Heart rate, postoperative nausea, vomiting,
shivering and sedation scores did not show any significant difference between the two groups
Conclusion: An infusion of dexmedetomidine at 0.75mcg/kg prior to extubation did not
affect the severity of cough but resulted in improved hemodynamics at predefined time points
Key words: dexmedetomidine